- #HIS RES PREVIEW FOR QUARK 2018 HOW TO#
- #HIS RES PREVIEW FOR QUARK 2018 UPDATE#
- #HIS RES PREVIEW FOR QUARK 2018 SOFTWARE#
The other trend this year is that the Alzheimer’s community focused on getting more and better access to data. This is a great example of how improving our understanding of biology will reduce both medical costs and human suffering. Another is that brain cells break down because part of the immune system gets overactivated and attacks them. One theory is that a patient’s brain cells break down because their energy producers (called mitochondria) wear out. In the past year, researchers have doubled down on a second generation of hypotheses. I hope these approaches pay off, but we have not seen much evidence that they will. The idea was to stop the plaques and tangles from forming.
These proteins cause plaques and tangles in the brain, clogging up and killing brain cells. The first generation of theories, which dominated the field for years, emphasized two proteins called amyloid and tau.
#HIS RES PREVIEW FOR QUARK 2018 HOW TO#
One is that researchers focused on a new set of ideas about how to stop Alzheimer’s. I saw two positive trends in Alzheimer’s research in 2018. Here are a few updates on what’s going well and what isn’t with innovation in some areas where I work. A lot of people underestimate just how much innovation will make life better. What connects it all is my belief that innovation can save lives and improve everyone’s well-being. Some of this is done through our foundation but a lot of it (such as my work on energy and Alzheimer’s work) is not. But there is nascent work in this field and I think it is going to accelerate.Īs I look back on the year, I am also thinking about the specific areas I work on. There are not the same clear measures of these things as there are for diseases, and there may never be.
#HIS RES PREVIEW FOR QUARK 2018 SOFTWARE#
For example, software will be able to notice when you’re feeling down, connect you with your friends, give you personalized tips for sleeping and eating better, and help you use your time more efficiently.
I think this will be the thrust of many big breakthroughs of the future. We still need a lot of innovation to solve problems like malaria or obesity, but we are also going to be focusing more on improving the quality of life. Technology has played a key role in that through vaccines, medicines, and improved sanitation. As a result, life spans have gone up dramatically. For most of human history, we have been focused on living longer by fighting disease and trying to grow enough food for everyone. It may sound grand, but I think the world is slowly going through a similar transition to a broader understanding of well-being. So has Warren Buffett, who says his measure of success is, “Do the people you care about love you back?” I think that is about as good a metric as you will find. Melinda has helped broaden my thinking on this point. Did I devote enough time to my family? Did I learn enough new things? Did I develop new friendships and deepen old ones? These would have been laughable to me when I was 25, but as I get older, they are much more meaningful. But I also ask myself a whole other set of questions about my life. Today of course I still assess the quality of my work. One thing that occurs to me is that the questions I am asking myself at age 63 are very different from the ones I would have asked when I was in my 20s.īack then, an end-of-year assessment would amount to just one question: Is Microsoft software making the personal-computing dream come true? I thought I would share a few of these thoughts as 2018 concludes. What was I excited about? What could I have done better? These days, at the end of each year, I still enjoy taking stock of my work and personal life. Some people think it is corny, but I like the tradition. Dad’s law firm is growing, Mom’s volunteer work is going strong, the girls are doing well in school, Bill is a handful.
#HIS RES PREVIEW FOR QUARK 2018 UPDATE#
Every Christmas when I was a kid, my parents would send out a card with an update on what the family was up to.